Welcome Note


Dear Colleagues,
It gives me the greatest pleasure to invite you to join us at 13th International Congress on Stem Cell Biology and Technology to be held in Tehran in September 2017. We have been featuring latest findings in this field since 2005 and we hope to follow in the successful footsteps of the meetings in 2017.
The program committee is planning a fabulous program ranging across the spectrum of stem cell science. The scientific exchange quality in previous meetings and increasing number of participants has made the congress a leading stem cell research and instructional meeting in the region. We will have 18th International congress on Reproductive Biomedicine in parallel to this event, which will be held by Royan Institute.
Royan institute was established in 1991 by the late Dr. Kazemi Ashtiani which is one of the most pioneering institutes conducting basic and translational research on stem cells, developmental biology and regenerative medicine. The members of the local organizing committee are very proud to be hosting the ICSCBT2017 and look forward to welcoming you to our city and country. Tehran and its environs are an amazing place to visit. Our multicultural city has many diverse neighborhoods of interest to visitors. The meeting promises to be highly rewarding on a social basis as well as on an intellectual basis.
 At the end of this Congress, we hope that attendees feel that they have garnered the most up-to-date information available in Developmental Biology.
 Please mark in your calendars the dates of the ICSCBT2017, September 2017, so that you may join your colleagues in what we hope will be a fantastic meeting.

Koorosh Shahpasand, Ph.D.

Congress Chairman of 13th Congress on Stem Cell Biology and Technology
   Scientific Background
I have had a long-term and intensive interest in Neurodegeneration mechanisms and possible therapeutics and have some ideas about my research directions. In particular, I’ve been investigating tau hyperphosphorylation and malfunction leading to Neurodegeneration. During my Master, I started to think about biological process and speculated the space which is required for organelle passage through axon and I reached to space-making protein “tau”. I looked deeper into literature and reached to tau phosphorylation and its possible effect on microtubule-spacing. Then, I published the hypothesis as an update article in Journal of Neuroscience Research. Moreover, I worked on effect of calcium, as a cation released during neuronal stress, on microtubule-spacing as my Master project in Tehran University.
Then I started to communicate with Prof. Shin-ichi Hisanaga, an expert neuroscientist in Tokyo Metropolitan University in Japan, and convinced him to work on the hypothesis as my PhD project. I chose AT8 phosphorylation site which is located on projection domain of tau and hyperphosphorylated during tauopathies. I demonstrated tau phosphorylation at AT8 site would indeed affect microtubule-spacing; resulting in mitochondrial movement deficiency. During the PhD course, I’ve juxtaposed the hypothetical problem and the experimental approaches by vigorous supporting data. I published the findings in Journal of Neuroscience.
To do my postdoc career, I decided to work on tau toxicity and chose Prof. Kun Ping Lu; a very famous scientist in Harvard Medical School. They had an ongoing project about cis / trans tau conformation upon phosphorylation at Thr231. I found cis pT231-tau is the central mediator of cell death upon various stresses both in vitro and in vivo and proved optional cis p-tau removal by monoclonal antibody blocks the neuronal cell death. We started to collaborate with several groups and published our findings as a Nature article.
Now, we are considering cistauosis in diverse neurodegenerative disorders and are exploring actual reason(s) of cis p-tau neurotoxicity. Moreover, we are looking for early diagnosis and treatment for tauopathies.